Aryl naphthyl methanone oxime(s) and process for preparation thereof

US9994515B2 · kind B2 · utility

Assignee

• COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH · IN

Inventors

• Sabyasachi Sanyal · Sidhauli, IN
• Atul Kumar · Lucknow, IN
• Naibedya Chattopadhyay · Lucknow, IN
• Jawahar Lal · Lucknow, IN
• Arun Kumar Trivedi · Lucknow, IN
• Dipak Datta · Lucknow, IN
• Srikanta Kumar Rath · Lucknow, IN
• Tahseen Akhtar · Lucknow, IN
• Shailendra Kumar Dhar Dwivedi · Lucknow, IN
• Manisha Yadav · Lucknow, IN
• Bandana Chakravarti · Lucknow, IN
• Abhishek Kumar Singh · Lucknow, IN
• Jay Sharan Mishra · Lucknow, IN
• Nidhi Singh · Meylan, FR
• Anil Kumar Tripathi · Panvel, IN

Key dates

• Filing date: Aug 29, 2014
• Grant date: Jun 12, 2018
• Expiry date: Sep 5, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D295/088
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to substituted aryl naphthyl methanone oximes of general formula (I), their process for preparation and their derivatives, salts, pharmaceutical composition thereof and their use in treatment of chronic myelogenous leukemia, acute myelogenous leukemia, lymphoma, multiple myeloma, solid tumor forming cell-lines including such as breast cancer, endometrial cancer colon cancer, prostate cancer and killing of drug resistant cancer stem cells, as subject in need thereof.