Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use

US9994528B2 · kind B2 · utility

Assignee

• CYTOKINETICS, INC. · US

Inventors

• Luke W. Ashcraft · San Francisco, US
• Gustave Bergnes · Pacifica, US
• Scott Collibee · South San Francisco, US
• Chihyuan Chuang · Millbrae, US
• Jeff Gardina · South San Francisco, US
• Bradley P. Morgan · Moraga, US
• Alex Muci · South San Francisco, US
• Xiangping Qian · Foster City, US
• Antonio Romero · San Mateo, US
• Jeffrey Warrington · San Mateo, US
• Zhe Yang · Daly City, US

Key dates

• Filing date: Aug 11, 2015
• Grant date: Jun 12, 2018
• Expiry date: Aug 11, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R2, R4, R5, R6, R7, R8, R9, X, Z1, Z2, Z3, Z4 and m are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof.Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.