Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof
US9994563B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 12, 2015 |
| Grant date | Jun 12, 2018 |
| Priority date | — |
| Expiry date | Nov 12, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/13
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.