Compound of 5-hydroxyl-1,7-naphthyridine substituted by aryl or heteroaryl, preparation method thereof and pharmaceutical use thereof

US9994566B2 · kind B2 · utility

Assignee

• Shenyang Sunshine Pharmaceutical Co., LTD · CN

Inventors

• Yunlong Zhou · Suzhou, CN
• Suixiong Cai · 安丰镇, CN
• Guangfeng Wang · Shanghai, CN
• Lingling Jiao · Taizhou City, CN
• Ping Min · Shanghai, CN
• Yu Jing · Suzhou, CN
• Ming Guo · Suzhou, CN

Key dates

• Filing date: Dec 14, 2015
• Grant date: Jun 12, 2018
• Expiry date: Dec 14, 2035

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P19/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are a compound of the following formula (I) or a pharmaceutically acceptable salt thereof, a preparation method thereof, pharmaceutical compositions and uses thereof in the preparation of a medicine for inhibiting HIF prolyl hydroxylase or a medicine for promoting the generation of endogenous EPO, wherein in the formula (I), R1 and R2 are each independently hydrogen; R3 is hydrogen or C1-3 alkyl; and Ar is an aromatic ring or an heteroaromatic ring selected from a naphthalene ring, a pyridine ring, a thiophene ring, a furan ring and a substituted benzene ring.