Self-regulated peptide hydrogel for insulin delivery
US9994615B2 · kind B2 · utility
3Cited by
5References
22Claims
0Family size
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Key dates
| Filing date | Feb 19, 2013 |
| Grant date | Jun 12, 2018 |
| Priority date | — |
| Expiry date | Feb 19, 2033 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A glucose binding amphiphilic peptide hydrogel insulin delivery system that is responsive to glucose concentrations under physiological conditions is provided. Insulin is encapsulated in a glucose binding hydrogel, made from self-assembling amphiphilic peptides including a hydrophobic domain including a beta sheet forming region coupled to a charged hydrophilic domain modified to contain a glucose binding segment. The formulations are designed to release insulin as a function of blood glucose level, maintaining the patients' blood glucose level in an optimum range and avoiding both hyper- and hypoglycemia.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.