Use of ligands for the programmed cell death receptor conjugated to solid supports for cultivating human regulatory T cells
US9994817B2 · kind B2 · utility
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Key dates
| Filing date | Aug 7, 2015 |
| Grant date | Jun 12, 2018 |
| Priority date | — |
| Expiry date | May 13, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2531/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are methods for isolating, cultivating, and/or cells including regulatory T cells (Tregs). The methods typically include cultivating cells including Tregs in a culture media comprising a ligand for programmed cell death receptor (PD-1) conjugated to a solid support. Suitable ligands may include PD-L1 and suitable solid supports may include magnetic or paramagnetic beads where the methods further include removing the PD-L1/bead conjugates after the Tregs have been isolated, cultured, and/or expanded.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.