Methods for enriching pluripotent stem cell-derived cardiomyocyte progenitor cells and cardiomyocyte cells based on SIRPA expression
US9994821B2 · kind B2 · utility
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12Claims
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Key dates
| Filing date | Aug 26, 2011 |
| Grant date | Jun 12, 2018 |
| Priority date | — |
| Expiry date | Dec 15, 2031 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/56966
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to in vitro methods of enriching populations of human pluripotent stem cells that are induced to differentiate to cardiomyocyte progenitor cells and cardiomyocyte cells. The cell populations can be enriched by isolating cells that express SIRPA. The invention also related to in vitro-enriched populations of cardiomyocyte cells and cardiomyocyte progenitor cells obtained from populations of pluripotent stem.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.