PEG-Prom mediated surface expression of avidin/streptavidin

US9994865B2 · kind B2 · utility

Assignees

• THE JOHNS HOPKINS UNIVERSITY · US
• Virginia Commonwealth University · US

Inventors

• Paul Fisher · Scarsdale, US
• Swadesh K. Das · Richmond, US
• Mitchell E. Menezes · Richmond, US
• Devanand Sarkar · Richmond, US
• Martin G. Pomper · Baltimore, US

Key dates

• Filing date: Jun 4, 2014
• Grant date: Jun 12, 2018
• Expiry date: Jun 4, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2830/008
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The presently disclosed subject matter relates to compositions and methods directed to cancer theranostic nucleic acid constructs that permit simultaneous cancer-specific viral replication, expression of a diagnostic gene product, and expression of a therapeutic gene.