Detecting neoplasm

US9994911B2 · kind B2 · utility

Assignees

• Mayo Foundation for Medical Education and Research · US
• Exact Sciences Development Company, LLC · US

Inventors

• David A. Ahlquist · Rochester, US
• John B. Kisiel · Rochester, US
• William R. Taylor · Lake City, US
• Tracy C. Yab · Rochester, US
• Douglas W. Mahoney · Elgin, US
• Graham P. Lidgard · Madison, US
• Hatim Allawi · Madison, US

Key dates

• Filing date: Mar 12, 2014
• Grant date: Jun 12, 2018
• Expiry date: Mar 12, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/154
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as pancreatic and colorectal cancer. Accordingly, provided herein is technology for pancreatic cancer screening markers and other gastrointestinal cancer screening markers that provide a high signal to-noise ratio and a low background level when detected from samples taken from a subject (e.g., stool sample). As described herein, the technology provides a number of methylated DNA markers and subsets thereof (e.g., sets of 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or more markers) with high discrimination for G1 neoplasms overall and/or at individual tumor sites.