Agents for treating disease

US9995733B2 · kind B2 · utility

Assignee

• Biotest AG · DE

Inventors

• Frank Osterroth · Dietzenbach, DE
• Christoph Uherek · Seligenstadt, DE
• Christoph Bruecher · Eschborn, DE
• Benjamin Daelken · Frankfurt am Main, DE
• André Engling · Frankfurt, DE
• Chantal Zuber · Frankfurt am Main, DE
• Niklas Czeloth · Dreieich, DE
• Holger Wallmeier · Pocking, DE
• Kirsten Völp · Karben, DE
• Gregor Schulz · Umkirch, DE

Key dates

• Filing date: May 30, 2012
• Grant date: Jun 12, 2018
• Expiry date: Dec 22, 2035

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/70514
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Provided are methods of screening to identify molecules capable of binding to CD4 and capable of activating CD4+CD25+ regulatory T cells. Further provided are antibodies and antibody fragments capable of activating CD4+CD25+ regulatory T cells and methods and uses involving the antibodies and fragments thereof.