Methods and systems for controlling oxidative stress in humans and animals
US9995758B1 · kind B1 · utility
Assignee
Inventor
Key dates
| Filing date | Oct 30, 2015 |
| Grant date | Jun 12, 2018 |
| Priority date | — |
| Expiry date | Feb 13, 2036 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/7009
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present application describes methods and systems for measuring and controlling oxidative stress in animals and humans. The degree of oxidative stress can be measured directly by inducing all of the blood cells to produce excessive reactive oxygen species (ROS) by exposure to an elevated concentration sulfide or other ROS inducing chemical and measuring the fluorescence intensity of a fluorescent dye or color intensity of dye that reacts with ROS. Oxidative stress can be reduced by reducing dietary sulfur, consumption of a methanogenic probiotic, or apheresis methods to replace ROS-positive blood cells with normal blood cells. Plasma oxidative stress can be compared in venous and arterial blood samples to evaluate small vessel disease. Oxidative stress can be increased by increasing dietary sulfur or the use of an intravenous method that exposes blood cells to an elevated blood concentration of sulfide or other ROS inducing chemical.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.