No-carrier-added (18F)-N-methylspiroperidol

USH1209H · kind H · statutory invention registration

Assignee

• The United States of America as represented by the United States · US

Inventors

• Chyng-Yann Shiue · East Setauket, US
• Joanna S. Fowler · Bellport, US
• Alfred P. Wolf · Setauket, US

Key dates

• Grant date: Jul 6, 1993

Classification

• Technology area (CPC —): General

Abstract

There is disclosed a radioligand labeled with a positron emitting radionuclide suitable for dynamic study in living humans with positron emission transaxial tomography. [.sup.18 F]-N-methylspiroperidol, exhibiting extremely high affinity for the dopamine receptors, provides enhanced uptake and retention in the brain concomitant with reduced radiation burden. These characteristics all combine to provide [.sup.18 F]-N-methylspiroperidol as a radioligand superior to known radioligands for mapping dopamine receptors in normal and disease states in the living brain. Additionally, a new synthetic procedure for this material is disclosed.