Enzymatic reduction method for the preparation of halohydrins

USH1893H · kind H · statutory invention registration

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Ramesh N. Patel · Bound Brook, US
• Laszlo J. Szarka · East Brunswick Township, US
• Amit Banerjee · Yardley, US
• Clyde G. McNamee · Lawrenceville, US

Key dates

• Grant date: Oct 3, 2000

Classification

• Technology area (CPC —): General

Abstract

An enzymatic reduction method, particularly a stereoselective enzymatic reduction method, for the preparation of halohydrins from haloketones. The halohydrin products are particularly useful in the preparation of epoxides, which may be employed as intermediates in the preparation of protease inhibitors such as retroviral protease inhibitors.