Synergistic effect of chemotherapeutic agents on beta-interferon
USH22H · kind H · statutory invention registration
1Cited by
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18Claims
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| Filing date | — |
| Grant date | Feb 4, 1986 |
| Priority date | — |
| Expiry date | — |
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- Technology area (CPC —)General
Abstract
A composition of matter exhibiting a synergistic cytotoxic effect in combination therapy of certain breast cancer and myeloma cell lines is prepared by combining synergistically effective amounts of 5-fluorouracil and human recombinant beta-interferon, optionally together with a pharmaceutically effective diluent or carrier. Preferably the recombinant beta-interferon is a mutein in which the cysteine residue at position 17 of native beta-interferon is replaced by a serine residue.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.