Patent · US Active

Plasmid for producing human insulin

USH245H · kind H · statutory invention registration

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10Claims
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Grant dateApr 7, 1987
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  • Technology area (CPC —)General

Abstract

Recombinant plasmids are described that carry the structural gene for human proinsulin in expressible form. The human proinsulin structural gene is fused to a functional transport sequence. Host organisms transformed by the recombinant plasmids express a preproinsulin in vivo, and is transported across the host organism's cell wall. Following its recovery, in vitro methods are used to convert the human proinsulin to human insulin.

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