Process for making compounds possessing anticholinesterase activity

USH346H · kind H · statutory invention registration

Assignee

• The United States of America as represented by the Secretary of the Army · US

Inventors

• Joseph Epstein · Beer Sheva, IL
• Harry O. Michel · Towson, US
• Robert E. Plapinger · Baltimore, US
• Joseph H. Fleisher · Baltimore, US
• John J. Callahan · Baltimore, US
• Bernard J. Jandorf · Baltimore, US

Key dates

• Grant date: Oct 6, 1987

Classification

• Technology area (CPC —): General

Abstract

The compounds of S-(2-dialkylaminoalkyl) alkyl phosphonothioic acids and hod of preparing said compounds possessing anticholinesterase activity comprising an aqueous solution which comprises dialkylaminoalkyl chloride salts which are converted to their corresponding dialkylmonoalkyl ammonium ions and alkylphosphonothioic acids forming a reaction mixture. The latter mixture is placed on a cation exchange resin with subsequent addition of water as an eluting agent giving rise to fractions containing the desired compounds.