5-Aryl-1H-1,5-benzodiazepine-2,4-diones

USRE28972E · kind E · reissue

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Karl-Heinz Weber · Gau-Algesheim, DE
• Herbert Merz · Ingelheim am Rhein, DE
• Karl Zeile
• Rolf Giesemann
• Peter Danneberg

Key dates

• Filing date: Dec 4, 1975
• Grant date: Sep 21, 1976
• Expiry date: Dec 4, 1995

Classification

• Technology area (CPC —): General

Abstract

5-Aryl-1H-1,5-benzodiazepine-2,4-diones of a formula selected from the group consisting of ##SPC1## Wherein ##SPC2## EQU -- A -- X wherein R.sub.1 is allyl, methylallyl, dimethylallyl, chloroallyl, cyclohexyl, cycloalkylmethyl, cycloalkenylmethyl of 4 to 7 carbon atoms, phenyl, tolyl, xylyl, methoxyphenyl, dimethoxyphenyl, halophenyl, phenylalkyl of 7 to 8 carbon atoms, pyridyl or EQU --A --X where A is straight or branched alkylene of 1 to 4 carbon atoms, and PA1 X is hydroxyl, alkoxy, acyloxy, dialkylamino of 2 to 4 carbon atoms, or a 5- to 6-membered nitrogen-containing heterocyclic ring linked to A through a ring nitrogen atom, PA1 R.sub.2 is hydrogen or methyl, PA1 R.sub.3 is naphthyl, pyrimidyl, thienyl, pyridyl, methylpyridyl or halopyridyl, PA1 R.sub.4 is hydrogen, methyl, methoxy, trifluoromethyl, cyano, halogen, lower alkanoyl or (lower alkoxy of 1 to 2 carbon atoms)-carbonyl, PA1 R.sub.5 is hydrogen, methyl, ethyl, methoxy, trifluoromethyl, cyano, nitro, halogen, lower alkanoyl or lower alkoxy-carbonyl, PA1 R.sub.6 is hydrogen, methyl, ethyl, methoxy or halogen, PA1 R.sub.7 is cyano.[.,.]. .Iadd.or .Iaddend.lower alkanoyl .[.or lower alkoxycarbonyl.]., PA1 R.sub.8 is cya…