Processes for stereospecifically preparing chiral 2-substituted-4-hydroxy-2-cyclopenten-1-one
USRE29990E · kind E · reissue
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Key dates
| Filing date | Nov 4, 1977 |
| Grant date | May 8, 1979 |
| Priority date | — |
| Expiry date | Nov 4, 1997 |
Classification
- Technology area (CPC —)General
Abstract
A method for stereospecifically preparing chiral 2-substituted-4-hydroxy-2-cyclopenten-1-one which comprises asymmetrically reducing 2-substituted cyclopentane-1,3,4-trione to the corresponding 2-substituted-4(R)-hydroxy-cyclopentane-1,3-dione, enolizing the said dione to obtain the enol ester or enol ether configuration, reducing the enol ester or ether and recovering the desired compound. The chiral 2-substituted-4-hydroxy-2-cyclopenten-1-one are key intermediates in the preparation of prostaglandins.
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