Process for preparation of 9-(dihalobenzyl)adenines

USRE31429E · kind E · reissue

Assignee

• MERCK & CO., INC. · US

Inventors

• Robert Tull · Levittown, US
• George D. Hartman · Lansdale, US
• Leonard M. Weinstock · Montgomery, US

Key dates

• Filing date: Oct 23, 1979
• Grant date: Oct 25, 1983
• Expiry date: Oct 23, 1999

Classification

• Technology area (CPC —): General

Abstract

9-(Dihalobenzyl)adenines are prepared uncontaminated with other positional isomers in a series of mild transformations starting from 4,5,6-triaminopyrimidine and proceeding via 7-(N-formyl-N-dihalobenzyl)amino[1,2,5]-thiadiazolo[3,4-d]pyrimidine. The resulting compounds have anticoccidial activity and are useful in controlling cecal and/or intestinal coccidiosis when administered in minor quantities to animals, in particular to poultry usually in admixture with animal sustenance.