Treatments employing drug-containing matrices for introduction into cellular lesion areas

USRE33375E · kind E · reissue

Assignee

• Matrix Pharmaceutical, Inc. · US

Inventors

• Edward E. Luck · Menlo Park, US
• Dennis M. Brown · Allentown, US

Key dates

• Filing date: Oct 11, 1988
• Grant date: Oct 9, 1990
• Expiry date: Oct 11, 2008

Classification

• Technology area (CPC —): General

Abstract

Treatment of cellular disorders involving abnormal solid cellular growths involves introduction of cytotoxic reagents dispersed in a physiologically acceptable proteinaceous matrix into the solid cellular growth or area of an existing or removed solid cellular growth. Enhanced effectiveness of the drug is observed, with reduced cytotoxic effects on cells distant from the site of introduction. Other drugs may be included to enhance therapeutic gain and reduce adverse affects to normal tissue.