Blood substitute

USRE34077E · kind E · reissue

Assignee

• Cryomedical Sciences, Inc. · US

Inventors

• Paul E. Segall · Berkeley, US
• Harold D. Waitz · Berkeley, US
• Hal Sternberg · Berkeley, US

Key dates

• Filing date: Oct 23, 1990
• Grant date: Sep 22, 1992
• Expiry date: Oct 23, 2010

Classification

• Technology area (CPC —): General

Abstract

A blood substitute suitable for replacing blood in mammalian subjects when performance of surgical procedures at hypothermic temperatures is described. The blood substitute comprises water, electrolytes at physiological concentration, dextran 40 at a concentration sufficient for the blood substitute to achieve a colloidal suspension having a fluid osmotic pressure essentially equivalent to mammalian plasma, HEPES buffer at a physiological pH, dextrose, magnesium ion at a concentration of about 0.01M and potassium ion at a concentration greater than 10 mEq per liter sufficient to prevent or arrest cardiac fibrillation. In one embodiment the blood substitute is a multi-solution system wherein the solutions comprise differing levels of the above-indicated componants and are administered sequentially to completely replace a subjects circulating blood.