Process for preparing taxol

USRE34277E · kind E · reissue

Assignee

• CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE · FR

Inventors

• Jean-Noel Denis · Saint-Martin-d'Hères, FR
• Andrew-Elliot Greene · Meylan, FR
• Daniel Guenard · Montrouge, FR
• Francoise Gueritte-Voegelein · Les Ulis, FR

Key dates

• Filing date: Nov 1, 1991
• Grant date: Jun 8, 1993
• Expiry date: Nov 1, 2011

Classification

• Technology area (CPC —): General

Abstract

Process for preparing taxol by the condensation of a (2R, 3S) acid of general formula (I) with a taxan derivative of general formula (II), followed by the removal of the groups R.sub.2 and R.sub.3 protecting the hydroxy groups .Iadd.and intermediates used therein.Iaddend.. ##STR1##