Benzonaphthalene derivatives, a process for their preparation and their use in therapeutic and cosmetic compositions

USRE34440E · kind E · reissue

Assignee

• Centre International de Recherches Dermatalogiques Galderma (C.I.R.D.) Galderma · FR

Inventors

• Braham Shroot · Antibes, FR
• Jacques Eustache · Grasse, FR
• Jean-Michel Bernardon · Le Rouret, FR

Key dates

• Filing date: Jul 16, 1992
• Grant date: Nov 9, 1993
• Expiry date: Jul 16, 2012

Classification

• Technology area (CPC —): General

Abstract

A benzonaphthalene compound has the formula ##STR1## wherein R.sub.1 represents ##STR2## or (ii) --CH.sub.2 OH; R.sub.6 represents ##STR3## or OR.sub.7 wherein R.sub.7 represents hydrogen, alkyl having 1-20 carbon atoms, monohydroxyalkyl or polyhydroxyalkyl, r' or r" represent hydrogen, lower alkyl, mono or polyhydroxyalkyl, aryl or a residue of an amino acid or a sugar, or together form a heterocycle; R.sub.2 represents hydrogen, alkyl having 1-15 carbon atoms, alkoxy having 1-4 carbon atoms or a cycloaliphatic radial; R.sub.3 represents hydrogen, hydroxy, alkyl having 1-4 carbon atoms, alkoxy having 1-10 carbon atoms, a cycloaliphatic radical, a thiocycloaliphatic radical or --O--Si(CH.sub.3).sub.2 --R.sub.8 wherein R.sub.8 represents lower alkyl; and R.sub.4 and R.sub.5 represent hydrogen, lower alkyl, hydroxy or lower acyloxy. This compound is useful in the topical and systemic treatment of dermatologic diseases and in the treatment of the degeneration of conjunctive tissues. The compound also possesses anti-tumor activity.