Method for preparing (+)-(2S,3S)-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-5H-1,5-benzothiaze pine-4-one and chlorinated derivatives thereof
USRE34935E · kind E · reissue
0Cited by
7References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 29, 1993 |
| Grant date | May 9, 1995 |
| Priority date | — |
| Expiry date | Apr 29, 2013 |
Classification
- Technology area (CPC —)General
Abstract
2-Aminothiophenol is reacted with methyl (-)-(2R,3S)-2,3-epoxy-3-(4-methoxyphenyl)propionate, and the intermediate methyl (2S,3S)-3-[(2-aminophenyl)thio]-2-hydroxy-3-(4-methoxyphenyl)propionate is cyclized in the presence of methanesulfonic acid, in the same vessel and without isolating said intermediate product, using e.g. chlorobenzene as a solvent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.