Lipophila derivatives of muramylpeptides having properties of activating macrophages and compositions containing them

USRE35706E · kind E · reissue

Assignee

• VACSYN Inc. · US

Inventors

• Nigel C. Phillips · Rue du Bois des Loges, CA
• Francoise Audibert · Neuilly-sur-Seine, FR
• Jean-Marie Bernard · Brignais, FR
• Louis Chedid · Paris, FR
• Pierre Lefrancier · Les Ulis, FR
• Michel Level · Paris, FR
• Monique Parant · Paris, FR

Key dates

• Filing date: Oct 25, 1994
• Grant date: Dec 30, 1997
• Expiry date: Oct 25, 2014

Classification

• Technology area (CPC —): General

Abstract

The invention relates to muramyleptide derivatives resulting essentially from the conjugation or the coupling, as the case may require, through an arm, between a muramylpeptide and a group containing two atoms contiguous with one another to each of which is attached a lipophile chain comprising from 8 to 100 carbon atoms, preferably from 14 to 24 carbon atoms. The derivatives according to the invention are endowed with remarkable stimulating properties with respect to the activation of macrophages, of which they amplify the tumoricidal properties.