Inhibitors of poly(ADP-ribose) synthetase and use thereof to treat NMDA neurotoxicity

USRE36397E · kind E · reissue

Assignees

• The John Hopkins University · US
• The United States of America · US

Inventors

• Jie Zhang · Beijing, CN
• Valina L. Dawson · Baltimore, US
• Ted M. Dawson · Baltimore, US
• Solomon H. Snyder · Baltimore, US

Key dates

• Filing date: Dec 23, 1998
• Grant date: Nov 16, 1999
• Expiry date: Dec 23, 2018

Classification

• Technology area (CPC —): General

Abstract

Inhibitors of poly(ADP-ribose) synthetase can be used to prevent neurotoxicity mediated through N-methyl-D-aspartate (NMDA) receptors. Poly(ADP-ribose) synthetase inhibitors can be used therapeutically in the treatment of vascular stroke and neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and Huntington's disease.