2-aralkoxy and 2-alkoxy adenosine derivatives as coronary vasodilators and antihypertensive agents
USRE36494E · kind E · reissue
Assignee
Inventors
Key dates
| Filing date | Jul 26, 1993 |
| Grant date | Jan 11, 2000 |
| Priority date | — |
| Expiry date | Jul 26, 2013 |
Classification
- Technology area (CPC —)General
Abstract
Compounds are disclosed having the formulae: ##STR1## .Iadd.wherein R' is hydrogen, lower alkyl or lower alkoxy; r is 0 or 1 and p is zero to four; and .Iaddend. PA1 wherein R.sub.1 is selected from the group, consisting of radicals represented by the general formulae: ##STR2## wherein Y is selected from the group consisting of lower alkyl, lower alkoxy, and halogen; Z is oxygen, sulfur or --NH, Q is --CH or nitrogen; a is zero or an integer of from one to three; and PA1 wherein, R.sub.2 is selected from the group consisting of hydrogen and straight chain, branched and cyclic hydrocarbyl radicals having from one to four carbon atoms, and optionally substituted with a hydroxyl radical; and PA1 wherein X is two hydrogen atoms or oxygen and B is selected from oxygen and nitrogen, and pharmaceutically acceptable salts thereof, with the proviso that when X is two hydrogen atoms, B is oxygen, and with the further proviso that when B is oxygen then R.sub.1 cannot be a phenyl or a substituted phenyl radical. Pharmaceutical preparations using these compounds and a method for inducing an adenosine response mediated by the adenosine A.sub.2 receptor by administering these compounds are also d…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.