APC gene and nucleic acid probes derived therefrom

USRE36713E · kind E · reissue

Assignees

• THE JOHNS HOPKINS UNIVERSITY · US
• University of Utah · US
• Zeneca Limited · GB
• The Cancer Institute · JP

Inventors

• Bert Vogelstein · Baltimore, US
• Kenneth W. Kinzler · Baltimore, US
• Hans Albertson · Salt Lake City, US
• Rakesh Anand · Rastatt, DE
• Mary Carlson · Salt Lake City, US
• Joanna Groden · Cincinnati, US
• Philip John Hedge · Grafton, GB
• Geoff Joslyn · Salt Lake City, US
• Alexander Fred Markham · Crewe, US
• Yusuke Nakamura · Bunkyo, JP
• Andrew Thliveris · Salt Lake City, US
• Raymond L. White · Salt Lake City, US

Key dates

• Filing date: Oct 4, 1996
• Grant date: May 23, 2000
• Expiry date: Oct 4, 2016

Classification

• Technology area (CPC —): General

Abstract

A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in hum tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as wel as in sporadic colorectal cancer patents. APC is expressed in most normal tissue. These results suggest that APC is a tumor suppressor.