Method to prevent fertilization in mammals by administering a single dose of zona pellucida derived antigens, liposome and adjuvant
USRE37224E · kind E · reissue
15Cited by
7References
20Claims
0Family size
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Key dates
| Filing date | Jul 23, 1998 |
| Grant date | Jun 12, 2001 |
| Priority date | — |
| Expiry date | Jul 23, 2018 |
Classification
- Technology area (CPC —)General
Abstract
A vaccine for the immunocontraception of mammals is described. The vaccine consists of zona pellucida antigens and an adjuvant encapsulated in a liposome delivery system. The liposome delivery system allows for the slow release of antigen resulting in a prolonged immune response. In particular, after a single injection of the vaccine, levels of anti-zona pellucida antibodies were detected for up to 22 months in seals. Thus, the vaccine according to the present invention is effective after a single dose and is therefore very useful in immunocontraceptive protocols.
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