Synthesis of tyrosine-derived diphenol monomers
USRE37795E1 · kind E1 · reissue
16Cited by
4References
14Claims
0Family size
Inventors
Key dates
| Filing date | Jul 21, 1999 |
| Grant date | Jul 16, 2002 |
| Priority date | — |
| Expiry date | Jul 21, 2019 |
Classification
- Technology area (CPC —)General
Abstract
A method for preparing diphenol compounds, which method includes the steps of coupling a hydroxyphenyl carboxylic acid with a L-tyrosine ester in a water-miscible organic reaction solvent containing a carbodiimide capable of forming a water-soluble urea by-product, thereby forming a diphenol reaction product; and combining the reaction mixture with an amount of water effective to precipitate the diphenol as a water-immiscible organic phase, so that a water-immiscible organic phase is formed containing the diphenol reaction product. New diphenol monomers and polymers polymerized therefrom are also discussed.
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