Kappa agonist compounds and pharmaceutical formulations thereof

USRE38133E1 · kind E1 · reissue

Assignee

• Adolor Corporation · US

Inventors

• Lawrence I. Kruse · Haddonfield, US
• An-Chih Chang · Phoenixville, US
• Diane L. DeHaven-Hudkins · Chester Springs, US
• John J. Farrar · Chester Springs, US
• Forrest Gaul · Douglassville, US
• Virendra Kumar · Paoli, US
• Michael Anthony Marella · Philadelphia, US
• Alan L. Maycock · Malvern, US
• Wei Zhang · San Diego, US

Key dates

• Filing date: Feb 4, 2002
• Grant date: Jun 3, 2003
• Expiry date: Feb 4, 2022

Classification

• Technology area (CPC —): General

Abstract

Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided.The compounds of formulae I, II, III and IV have the structure: wherein:X, X4, X5, X7, X9;R1, R2, R3, R4; andY, Z and n are as described in the specification.