Solid oral dosage form comprising a combination of metformin and glibenclamide

USRE38629E1 · kind E1 · reissue

Assignee

• Merck Sante · FR

Inventors

• Yves Bonhomme · Amilly, FR
• Geoffrey Nicholson · Woodbury, US
• Gillian Cave · Ellesmere Port, GB
• Sarah J. Nicholson · Helsby, GB

Key dates

• Filing date: Dec 27, 2002
• Grant date: Oct 19, 2004
• Expiry date: Dec 27, 2022

Classification

• Technology area (CPC —): General

Abstract

The present invention relates to a solid oral dosage form comprising a combination of metformin and glibenclamide in which the size of glibenclamide is such that the glibenclamide bioavailability is comparable to the glibenclamide bioavailability obtained with a separate administration of metformin and glibenclamide.