APC Antibodies

USRE38916E1 · kind E1 · reissue

Assignees

• THE JOHNS HOPKINS UNIVERSITY · US
• University of Utah · US
• The Cancer Institute · JP
• Zeneca Limited · GB

Inventors

• Bert Vogelstein · Baltimore, US
• Kenneth W. Kinzler · Baltimore, US
• Hans Albertsen · Salt Lake City, US
• Rakesh Anand · Rastatt, DE
• Mary Carlson · Salt Lake City, US
• Joanna Groden · Cincinnati, US
• Philip John Hedge · Grafton, GB
• Geoff Joslyn · Salt Lake City, US
• Alexander Fred Markham · Crewe, US
• Yusuka Nakamura · Tokyo, JP
• Andrew Thilveris · Madison, US
• Raymond L. White · Salt Lake City, US

Key dates

• Filing date: Nov 18, 1999
• Grant date: Dec 6, 2005
• Expiry date: Nov 18, 2019

Classification

• Technology area (CPC —): General

Abstract

A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.