INGAP protein involved in pancreatic islet neogenesis

USRE39062E1 · kind E1 · reissue

Assignees

• McGill University · CA
• Eastern Virginia Medical School of the Medical College of Hampton · US

Inventors

• Aaron I. Vinik · Norfolk, US
• Gary L. Pittenger · Virginia Beach, US
• Ronit Rafaeloff-Phail · Chesapeake, US
• Lawrence Rosenberg · Montréal, CA
• William P. Duguid · Montréal, CA

Key dates

• Filing date: Nov 22, 2000
• Grant date: Apr 11, 2006
• Expiry date: Nov 22, 2020

Classification

• Technology area (CPC —): General

Abstract

Cellophane wrapping (CW) of hamster pancreas induces proliferation of duct epithelial cells followed by endocrine cell differentiation and islet neogenesis. Using the mRNA differential display technique a cDNA clone expressed in cellophane wrapped but not in control pancreata was identified. Using this cDNA as a probe, a cDNA library was screened and a gene not previously described was identified and named INGAP.