Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof

USRE39146E1 · kind E1 · reissue

Assignee

• Bracco International BV · NL

Inventors

• Pascal Grenier · Ségny, FR
• Feng Yan · Carouge, CH
• Jerome Puginier · Cluses, FR
• Marie-Bernadette Barrau · Geneva, CH
• Philippe Bussat · Cognac, FR
• Eva Hybl · Heidelberg, DE
• Daniel Bichon · Montpellier, FR
• Michel Schneider · Troinex, CH

Key dates

• Filing date: Jul 15, 1998
• Grant date: Jun 27, 2006
• Expiry date: Jul 15, 2018

Classification

• Technology area (CPC —): General

Abstract

One can impart outstanding resistance against collapse under pressure to gas-filled microvesicle used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.