Method for preparing two-layer bicomposite collagen material for preventing post-operative adhesions
USRE39172E1 · kind E1 · reissue
Assignee
Inventors
Key dates
| Filing date | Sep 16, 1999 |
| Grant date | Jul 11, 2006 |
| Priority date | — |
| Expiry date | Sep 16, 2019 |
Classification
- Technology area (CPC —)General
Abstract
A bicomposite material based on collagen is prepared which has two closely bound layers and is biocompatible, non-toxic, hemostatic and biodegradable in less than a month, and can be used in surgery to achieve hemostasis and prevent post-surgical adhesion. To prepare the material, a solution of collagen or gelatin, which may contain glycerine and a hydrophilic additive such as polyethylene glycol or a polysaccharide, is poured onto an inert support to form a layer 30 μm to less than 100 μm thick. Then a polymeric porous fibrous layer is applied during gelling of the collagen or gelatin, and the resultant material is dried. The polymeric porous fibrous layer may be made of collagen or a polysaccharide, and have a density of not more than 75 mg/cm2, a pore size from 30 μm to 300 μm and a thickness of 0.2 cm to 1.5 cm.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.