INGAP protein involved in pancreatic islet neogenesis

USRE39299E1 · kind E1 · reissue

Assignees

• Eastern Virginia Medical School of the Medical College of Hampton · US
• McGill University · CA

Inventors

• William P. Duguid · Montréal, CA
• Gary L. Pittenger · Virginia Beach, US
• Ronit Rafaeloff-Phail · Chesapeake, US
• Lawrence Rosenberg · Montréal, CA
• Aaron I. Vinik · Norfolk, US

Key dates

• Filing date: Nov 13, 2000
• Grant date: Sep 19, 2006
• Expiry date: Nov 13, 2020

Classification

• Technology area (CPC —): General

Abstract

Cellophane wrapping (CW) of hamster pancreas induces proliferation of duct epithelial cells followed by endocrine cell differentiation and islet neogenesis. Using the mRNA differential display technique a cDNA clone expressed in cellophane wrapped but not in control pancreata was identified. Using this cDNA as a probe, a cDNA library was screened and a gene not previously described was identified and named INGAP.