Supplemented and unsupplemented tissue sealants, methods of their production and use

USRE39321E1 · kind E1 · reissue

Assignee

• The American National Red Cross · US

Inventors

• Martin MacPhee · Santa Rosa, US
• William N. Drohan · Springfield, US
• Gene Liau · Wayland, US
• Hernan Nunez · Derwood, US
• Wilson Burgess · Clifton, US
• Jeffrey O. Hollinger · Bethesda, US
• Thomas Maciag · Rockville, US

Key dates

• Filing date: Jun 20, 2003
• Grant date: Oct 3, 2006
• Expiry date: Jun 20, 2023

Classification

• Technology area (CPC —): General

Abstract

This invention provides a fibrin sealant dressing, wherein said fibrin sealant may be supplemented with at least one composition selected from, for example, one or more regulatory compounds, antibody, antimicrobial compositions, analgesics, anticoagulants, antiproliferatives, antiinflammatory compounds, cytokines, cytotoxins, drugs, growth factors, interferons, hormones, lipids, demineralized bone or bone morphogenetic proteins, cartilage inducing factors, oligonucleotides polymers, polysaccharides, polypeptides, protease inhibitors, vasoconstrictors or vasodilators, vitamins, minerals, stabilizers and the like. Also disclosed are methods of preparing and/or using the unsupplemented or supplemented fibrin sealant dressing.