Preparation of agarose coated, solid agarose-collagen beads containing secretory cells
USRE39542E1 · kind E1 · reissue
Assignee
Inventors
Key dates
| Filing date | Jan 2, 2003 |
| Grant date | Apr 3, 2007 |
| Priority date | — |
| Expiry date | Jan 2, 2023 |
Classification
- Technology area (CPC —)General
Abstract
Biological agents such as secretory cells are encapsulated in a hydrophilic gel made of agarose or collagen-agarose and gelatin sponge-agarose combinations. In a preferred embodiment, semi-solid beads are formed from a suspension containing collagen, agarose and secretory cells such as pancreatic islets, the collagen is polymerized to form solid, agarose-collagen beads and the solid beads are coated with agarose. Coating is preferably by rolling the solid beads in about 5-10% agarose, contacting the rolled beads with mineral oil and washing oil from the beads. Beads containing secretory cells can be transplanted into a mammal to treat a condition caused by impaired secretory cell function.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.