Nucleic acid molecules encoding the MAGE-1 tumor rejection antigen precursor

USRE40089E1 · kind E1 · reissue

Assignee

• LUDWIG INSTITUTE FOR CANCER RESEARCH LTD · GB

Inventors

• Thierry Boon-Falleur · Brussels, BE
• Pierre van der Bruggen · Brussels, BE
• Benoit Van den Eynde · Brussels, BE
• Aline Van Pel · Brussels, BE
• Etienne De Plaen · Brussels, BE
• Christophe Lurquin · Brussels, BE
• Patrick Chomez · Brussels, BE
• Catia Traversari · Milano, IT

Key dates

• Filing date: Jan 24, 1996
• Grant date: Feb 19, 2008
• Expiry date: Jan 24, 2016

Classification

• Technology area (CPC —): General

Abstract

The invention relates to an isolated DNA sequence which codes for an antigen expressed by tumor cells which is recognized by cytotoxic T cells, leading to lysis of the tumor which expresses it. Also described are cells transfected by the DNA sequence, and various therapeutic and diagnostic uses arising out of the properties of the DNA and the antigen for which it codes.