Therapeutic uses of di-aryl acid derivatives

USRE40558E1 · kind E1 · reissue

Assignee

• Sanofi-Aventis Deutschland GMBH · DE

Inventors

• Zaid Jayyosi · Flemington, US
• Gerard McGeehan · Chester Springs, US
• Michael Kelley · Arlington, US
• Richard F. Labaudiniere · Sherborn, US
• Litao Zhang · Nazareth, US
• Robert D. Groneberg · Boulder, US
• Daniel McGarry · King of Prussia, US
• Thomas J. Caulfield · Lawrenceville, US
• Anne Minnich · Flemington, US
• Mark Bobko · Exton, US

Key dates

• Filing date: Oct 20, 2005
• Grant date: Oct 28, 2008
• Expiry date: Oct 20, 2025

Classification

• Technology area (CPC —): General

Abstract

The use of diaryl acid derivatives of formula (I) or pharmaceutically acceptable salts, N-oxides, hydrates or solvates thereof, wherein the variables shown are defined in the disclosure, and their pharmaceutical compositions as PPAR ligand receptor binders. The PPAR ligand receptor binders of this invention are useful as agonists or antagonists of the PPAR receptor.