3,3-diphenylpropylamines, their use and preparation

USRE40851E1 · kind E1 · reissue

Assignee

• Pfizer Health AB · SE

Inventors

• Rolf Johansson · Huddinge, SE
• Pinchas Moses · Boo, SE
• Lisbeth Nilvebrant · Bromma, SE
• Bengt Sparf

Key dates

• Filing date: Nov 5, 1993
• Grant date: Jul 14, 2009
• Expiry date: Nov 5, 2013

Classification

• Technology area (CPC —): General

Abstract

The invention relates to 3,3-diphenylpropylamines of formula (I), wherein R1 signifies hydrogen or methyl, R2 and R3 independently signify hydrogen, methyl, methoxy, hydroxy, carbamoyl, sulphamoyl or halogen, and X represents a tertiary amino group of formula (II), wherein R4 and R5 signify non-aromatic hydrocarbyl groups, which may be the same or different and which together contain at least three carbon atoms, and wherein R4 and R5 may form a ring together with the amine nitrogen, their salts with physiologically acceptable acids and, when the compounds can be in the form of optical isomers, the racemic mixture and the individual enantiomers. The invention also relates to methods for their preparation, pharmaceutical compositions containing the novel compounds, and the use of the compounds for preparing drugs