APC antibodies

USRE40948E1 · kind E1 · reissue

Assignees

• THE JOHNS HOPKINS UNIVERSITY · US
• Astrazeneca United Kingdom, Ltd. · GB
• Cancer Institute, Japanese, Foundation for Cancer Research · JP
• University of Utah · US

Inventors

• Bert Vogelstein · Baltimore, US
• Kenneth W. Kinzler · Baltimore, US
• Hans Albertsen · Salt Lake City, US
• Rakesh Anand · Rastatt, DE
• Mary Carlson · Salt Lake City, US
• Joanna Groden · Cincinnati, US
• Philip John Hedge · Grafton, GB
• Geoff Joslyn · Salt Lake City, US
• Alexander Fred Markham · Crewe, US
• Yusuke Nakumura · Tokyo, JP
• Andrew Thliveris · Salt Lake City, US
• Raymond L. White · Salt Lake City, US

Key dates

• Filing date: Oct 24, 2001
• Grant date: Oct 27, 2009
• Expiry date: Oct 24, 2021

Classification

• Technology area (CPC —): General

Abstract

A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.