Method for producing 5-aryl nicotinaldehydes

USRE41008E1 · kind E1 · reissue

Assignee

• Merck Patent GmbH · DE

Inventors

• Andreas Bathe · Darmstadt, DE
• Heinz-Hermann Bokel · Darmstadt, DE
• Ralf Knieriemen · Groß-Zimmern, DE
• Christoph Muermann
• Thomas Keil · Marl, DE

Key dates

• Filing date: Jan 5, 2001
• Grant date: Nov 24, 2009
• Expiry date: Jan 5, 2021

Classification

• Technology area (CPC —): General

Abstract

The invention relates to a process for the preparation of 5-arylnicotinaldehydes by reduction of the corresponding 5-arylnicotinic acids by catalytic hydrogenation in the presence of carboxylic anhydrides in which the catalyst used is a palladium/ligand complex, characterized in that the molar ratio between palladium and ligand is from 1:5 to 1:15 in the case of monodentate ligands and from 1:2.5 to 1:7.5 in the case of bidentate ligands.