Oral pulsed dose drug delivery system

USRE41148E1 · kind E1 · reissue

Assignee

• Shire Laboratories, Inc. · US

Inventors

• Beth A. Burnside · Bethesda, US
• Xiaodi Guo · Derwood, US
• Kimberly Fiske · Downingtown, US
• Richard A. Couch · Bethesda, US
• Donald Treacy · Woodbine, US
• Rong-Kun Chang · Rockville, US
• Edward M. Rudnic · Potomac, US
• Charlotte M. McGuinness · Bethesda, US

Key dates

• Filing date: Oct 20, 1999
• Grant date: Feb 23, 2010
• Expiry date: Oct 20, 2019

Classification

• Technology area (CPC —): General

Abstract

A multiple pulsed dose drug delivery system for pharmaceutically active amphetamine salts, comprising an immediate-release component and an enteric delayed-release component wherein (1) the enteric release coating has a defined minimum thickness and/or (2) there is a protective layer between the pharmaceutically active amphetamine salt and the enteric release coating and/or (3) there is a protective layer over the enteric release coating. The product can be composed of either one or a number of beads in a dosage form, including either capsule, tablet, or sachet method for administering the beads.