Multi-tier method of developing localized calibration models for non-invasive blood analyte prediction
USRE41333E1 · kind E1 · reissue
Assignee
Inventors
Key dates
| Filing date | Jan 27, 2005 |
| Grant date | May 11, 2010 |
| Priority date | — |
| Expiry date | Jan 27, 2025 |
Classification
- Technology area (CPC —)General
Abstract
A method of multi-tier classification and calibration in noninvasive blood analyte prediction minimizes prediction error by limiting co-varying spectral interferents. Tissue samples are categorized based on subject demographic and instrumental skin measurements, including in vivo near-IR spectral measurements. A multi-tier intelligent pattern classification sequence organizes spectral data into clusters having a high degree of internal consistency in tissue properties. In each tier, categories are successively refined using subject demographics, spectral measurement information and other device measurements suitable for developing tissue classifications.The multi-tier classification approach to calibration utilizes multivariate statistical arguments and multi-tiered classification using spectral features. Variables used in the multi-tiered classification can be skin surface hydration, skin surface temperature, tissue volume hydration, and an assessment of relative optical thickness of the dermis by the near-IR fat band. All tissue parameters are evaluated using the NIR spectrum signal along key wavelength segments.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.