Synthesis of epothilones, intermediates thereto, analogues and uses thereof

USRE41990E1 · kind E1 · reissue

Assignee

• Sloan Kettering Institute for Cancer Research · US

Inventors

• Samuel J. Danishefsky · New Haven, US
• Peter Bertinato · Old Lyme, US
• Dai-Shi Su · New York, US
• Dongfang Meng · Morganville, US
• Ting-Chao Chou · Paramus, US
• Ted Kamenecka · New York, US
• Erik Sorensen · Village of La Jolla, US
• Aaron Balog · Lambertville, US
• Kenneth A. Savin · New York, US

Key dates

• Filing date: Jan 4, 2007
• Grant date: Dec 7, 2010
• Expiry date: Jan 4, 2027

Classification

• Technology area (CPC —): General

Abstract

The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.