Compositions and methods for enhancing receptor-mediated cellular internalization
USRE42072E1 · kind E1 · reissue
Assignees
Inventors
Key dates
| Filing date | Jun 21, 2007 |
| Grant date | Jan 25, 2011 |
| Priority date | — |
| Expiry date | Jun 21, 2027 |
Classification
- Technology area (CPC —)General
Abstract
Compositions and methods for improving cellular internalization of one or more compounds are disclosed. The compositions include a compound to be delivered and a biocompatible viscous material, such as a hydrogel, lipogel, or highly viscous sol. The composition also include, or are administered in conjunction with, an enhancer in an amount effective to maximize expression of or binding to receptors and enhance RME of the compound into the cells. This leads to high transport rates of compounds to be delivered across cell membranes, facilitating more efficient delivery of drugs and diagnostic agents. Compositions are applied topically orally, nasally, vaginally, rectally, and ocularly. The enhancer is administered with the composition or separately, either systemically or preferably locally. The compound to be delivered can also be the enhancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.