Quinazoline derivatives and pharmaceutical compositions containing them

USRE42353E1 · kind E1 · reissue

Assignee

• AstraZeneca UK Limited · GB

Inventors

• Andrew Peter Thomas · Cambridge, GB
• Craig Johnstone · Abingdon, GB
• Edward Clayton · Macclesfield, GB
• Elaine Sophie Elizabeth Stokes · Macclesfield, GB
• Jean-Jacques Marcel Lohmann · Tinqueux, FR
• Laurent Francois Andre Hennequin · Reims, FR

Key dates

• Filing date: Sep 23, 1997
• Grant date: May 10, 2011
• Expiry date: Sep 23, 2017

Classification

• Technology area (CPC —): General

Abstract

The invention relates to quinazoline derivatives of formula (1)wherein m is an integer from 1 to 2; R1 represents hydrogen, hydroxy, halogeno, nitro, trifluoromethyl, cyano, C1-3alkyl, C1-3alkoxy, C1-3alkylthio, or —NR5R6 (wherein R5 and R6, which may be the same or different, each represents hydrogen or C1-3alkyl); R2 represents hydrogen, hydroxy, halogeno, methoxy, amino or nitro; R3 represents hydroxy, halogeno, C1-3alkyl, C1-3alkoxy, C1-3alkanoyloxy, trifluoromethyl, cyano, amino or nitro; X1 represents —O—, —CH2—, —S—, —SO—, —SO2—, —NR7CO—, —CONR8—, —SO2NR9—, —NR10SO2— or —NR11— (wherein R7, R8, R9, R10 and R11 each independently represents hydrogen, C1-3alkyl or C1-3alkoxyC2-3alkyl); R4 represents an optionally substituted 5 or 6 membered saturated carbocyclic or heterocyclic group or a group which is alkenyl, alkynyl or optionally substituted alkyl, which alkyl group may contain a heteroatom linking group, which alkenyl, alkynyl or alkyl group may carry a terminal optionally substituted group selected from alkyl and a 5 or 6 membered saturated carbocyclic or heterocyclic group, and salts thereof; processes for their preparation, pharmaceutical compositions containing a compo…