Anti-MIF antibodies

USRE43497E1 · kind E1 · reissue

Assignee

• Max-Planck-Gesellschaft zur Föderung der Wissenschaften e.V. · US

Inventors

• Herwig Brunner · Stuttgart, DE
• Jurgen Bernhagen · Tübingen, DE
• Robert Kleemann · Delft, NL
• Ralf Mischke · Biberach, DE
• Afroditi Kapurniotu · Aachen, DE

Key dates

• Filing date: Nov 2, 2000
• Grant date: Jun 26, 2012
• Expiry date: Nov 2, 2020

Classification

• Technology area (CPC —): General

Abstract

The present invention relates to methods for screening molecules and methods to detect protein-protein interactions and means used therein. More specifically, the present invention relates to methods for screening candidate drugs for treating or detecting MIF (macrophage migration inhibitor factor) related diseases. In certain aspects, the present invention involves detecting MIF/Jab1 (c-Jun activation domain binding protein) interactions as a basis for modulating cellular regulatory pathways and for identifying candidate drugs for MIF-related diseases. The invention also provides methods for the identification of molecules which dissociate or prevent interaction or binding between MIF and Jab1.